The prefrontal cortex is widely believed to play an important role in facilitating people's ability to switch performance between different tasks. We present a biologically‐based computational model of prefrontal cortex (PFC) that explains its role in task switching in terms of the greater flexibility conferred by activation‐based working memory representations in PFC, as compared with more slowly adapting weight‐based memory mechanisms. Specifically we show that PFC representations can be rapidly updated when a task switches via a dynamic gating mechanism based (...) on a temporal‐differences reward‐prediction learning mechanism. Unlike prior models of this type, the present model develops all of its internal representations via learning mechanisms as shaped by the demands of continuous periodic task switching. This advance opens up a new domain of research into the interactions between working memory task demands and the representations that develop to meet them. Results on a version of the Wisconsin card sorting task are presented for the full model and a number of comparison networks that test the importance of various model features. Furthermore, we show that a lesioned model produces perseverative errors like those seen in frontal patients. (shrink)

The prefrontal cortex is widely believed to play an important role in facilitating people's ability to switch performance between different tasks. We present a biologically‐based computational model of prefrontal cortex (PFC) that explains its role in task switching in terms of the greater flexibility conferred by activation‐based working memory representations in PFC, as compared with more slowly adapting weight‐based memory mechanisms. Specifically we show that PFC representations can be rapidly updated when a task switches via a dynamic gating mechanism based (...) on a temporal‐differences reward‐prediction learning mechanism. Unlike prior models of this type, the present model develops all of its internal representations via learning mechanisms as shaped by the demands of continuous periodic task switching. This advance opens up a new domain of research into the interactions between working memory task demands and the representations that develop to meet them. Results on a version of the Wisconsin card sorting task are presented for the full model and a number of comparison networks that test the importance of various model features. Furthermore, we show that a lesioned model produces perseverative errors like those seen in frontal patients. (shrink)

This article addresses the data protection and product safety regulatory models currently applied to consumer-facing health technologies. It explains how the design and structures of existing data protection and safety regulation in the U.S. have resulted in exceptionally thin protection for the users of consumer-facing devices and products that rely on or that facilitate consumer collection or aggregation of health and wellness data. It also examines some appealing legislative alternatives to the current thin model used in the U.S. and suggests (...) a framework for prioritizing ameliorative regulation. To better understand existing regulatory models, their deficiencies, and how they should be reformed, the article employs an analytical model describing these regulatory systems across two axes. The vertical axis describes the quantity or depth of regulation, such as, for example, the strictness of the rules imposed by the regulatory model. The horizontal axis describes the reach of the regulation, the behaviors, products, or industries to which the regulation applies. (shrink)

This article presents the results of methodological experimentation that utilises machine learning to investigate automated copyright enforcement on YouTube. Using a dataset of 76.7 million YouTube videos, we explore how digital and computational methods can be leveraged to better understand content moderation and copyright enforcement at a large scale.We used the BERT language model to train a machine learning classifier to identify videos in categories that reflect ongoing controversies in copyright takedowns. We use this to explore, in a granular way, (...) how copyright is enforced on YouTube, using both statistical methods and qualitative analysis of our categorised dataset. We provide a large-scale systematic analysis of removals rates from Content ID’s automated detection system and the largely automated, text search based, Digital Millennium Copyright Act notice and takedown system. These are complex systems that are often difficult to analyse, and YouTube only makes available data at high levels of abstraction. Our analysis provides a comparison of different types of automation in content moderation, and we show how these different systems play out across different categories of content. We hope that this work provides a methodological base for continued experimentation with the use of digital and computational methods to enable large-scale analysis of the operation of automated systems. (shrink)

The growing popularization of stakeholder theory among management scholars has offered a useful framework for understanding the multiple and interdependent roles of government and business in an increasingly challenging political and regulatory environment. Despite this trend, attention to the role and responsibility of government to protect citizen rights has been limited. To the two traditional stakeholder theory views of government where the focal organization remains the firm, we propose to add two views by pivoting the government’s place and making it (...) the focal organization. We thus describe governments as serving four roles in the business–government–society nexus. For each role, we analyze typical governmental activities/behaviors, relationships with firms’ stakeholders, as well as the challenges and limits to these roles. We also focus on the central notion of salience amplification, as a means of checks and balances across stakeholders in order to safeguard citizen rights and reveal the greater good. (shrink)

To analyze the relations between art and science, philosophers and historians have developed different lines of inquiry. A first type of inquiry considers how artistic and scientific practices have interacted over human history. Another project aims to determine the contributions that scientific research can make to our understanding of art, including the contributions that cognitive science can make to philosophical questions about the nature of art. We rely on contributions made to these projects in order to demonstrate that art and (...) science are codependent phenomena. Specifically, we explore the codependence of art and science in the context of a historical analysis of their interactions and in the context of contemporary debates on the cognitive science of art. (shrink)

The planning/control distinction is an important tool in the study of sensorimotor transformations. However, published data from our laboratories suggest that, contrary to what is predicted by the proposed model, (1) structures in the superior parietal lobe of both monkeys and humans can be involved in movement planning; and (2) fast pointing actions can be immune to visual illusions even if they are performed without visual feedback. The planning–control model as proposed by Glover is almost certainly too schematic.

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Human control of action in routine situations involves a flexible interplay between (a) task-dependent serial ordering constraints; (b) top-down, or intentional, control processes; and (c) bottom-up, or environmentally triggered, affordances. In addition, the interaction between these influences is modulated by learning mechanisms that, over time, appear to reduce the need for top-down control processes while still allowing those processes to intervene at any point if necessary or if desired. We present a model of the acquisition and control of goal-directed action (...) that goes beyond existing models by operationalizing an interface between two putative systems—a routine and a non-routine system—thereby demonstrating how explicitly represented goals can interact with the emergent task representations that develop through learning in the routine system. The gradual emergence of task representations offers an explanation for the transfer of control with experience from the non-routine goal-based system to the routine system. At the same time it allows action selection to be sensitive both to environmental triggers and to biasing from multiple levels within the goal system. (shrink)

Institutional Review Boards have expressed concern that research into sensitive topics such as mental disorder will cause participants undue distress. This study investigated the emotional responses of 5,220 Australians to a survey on mental-health-related discrimination. Participants were interviewed about their mental health and experiences of discrimination across 10 life domains and then the emotional impacts of the survey. Results suggested that a minority experienced a negative reaction in contrast to 88% reporting positive experiences. A mental health problem was associated with (...) both negative and positive reactions. (shrink)

Software plays an important role in contemporary research. Aside from its use for administering traditional instruments like surveys and in data analysis, the widespread use of mobile and web apps for social, medical and lifestyle engagement has led to software becoming a research intervention in its own right. For example, it is not unusual to find apps being studied for their utility as interventions in health and social life. Since the software may persist in use beyond the life of an (...) investigation, this raises questions as to the extent of ethical duties for researchers involved in its production and/or study towards the participants involved. Key factors identified include the extent of affect created by the software, the effect it has on a participant’s life, the length of investigation, cost of maintenance and participant agency. In this article we discuss the issues raised in such situations, considering them in the context of post-research duties of care and suggesting strategies to balance the burden on researchers with the need for ongoing participant support. (shrink)

À propos de Ludovic Chemarin© est un entretien entre Damien Beguet, Perrine Lacroix et P. Nicolas Ledoux réalisé pour la première apparition public du projet Ludovic Chemarin© à La BF15 (Lyon) en 2011. Cette discussion entre la responsable du lieu et les deux artistes permet de mieux cerner les enjeux conceptuels et formels d’un dispositif complexe et critique. Ce texte est un témoignage mais il a été depuis mis en forme et présenté régulièrement sous la forme d’affiches dans le (...) cadre d’expositions aux côté de documents (contrats, produits dérivés) et de pièces de l’artiste. Il fait œuvre et participe au brouillage de l’entreprise Ludovic Chemarin©. (shrink)

Knowing the individual skills and competences of one's group members may be important for deciding from whom to learn (social learning), with whom to collaborate and whom to follow. We investigated whether 12 jackdaws could select conspecifics based on their helping skills, which had been exhibited in a previous context. The birds were tested in a blocked-exit-situation, where they could choose between two conspecifics, one of which could be recruited inside. One conspecific had previously displayed the ability to open the (...) exit door whilst the other individual lacked the skill. The subjects showed a significant preference for the skilled conspecific if they had previously directly benefited from this skill. If they had merely observed the skilled (and non-skilled) individual opening (or failing to open) the exit door, they did not preferably choose the skilled conspecific. Taken together, these results suggest that jackdaws are capable of assessing other individuals' competence under certain circumstances. (shrink)

Fille de l’Encyclopédie (1751-1772, 28 vol.) de Diderot et d’Alembert, l’Encyclopédie méthodique (1782-1832, 212 vol.) de Panckoucke conserve la palme du gigantisme. Si la Révolution Française pendant laquelle est publié le Dictionnaire de Théologie, n’a rien changé ni aboli dans le domaine de la pensée, elle a changé les conditions d’exercice pour les directeurs scientifiques. De surcroit en synthétisant ce moment particulier des savoirs liant mots et choses, la Méthodique représente un chainon incontournable entre l’épistémé des Lumières et celle du (...) xixè siècle. Alors que l’Encyclopédie dans un Système figuré des connaissances humaines construisait un ordre encyclopédique à partir des trois facultés de l’entendement humain (mémoire, raison, imagination), Panckoucke, qui craint la polémique sur les renvois, réoriente cet ordre. Il découpe chaque article et organise des listes de matières à partir de l’Encyclopédie. L’ordre des matières ne vise que les choses de la science qui, dans chaque Dictionnaire, seront détaillées au mieux. Enfin pour conduire le lecteur dans la connaissance, une table analytique propose un ordre de lecture transformant le dictionnaire en traité didactique. Le Dictionnaire de Théologie relève un autre aspect de la pensée philosophique du Système figuré, à savoir, une séparation de la Théologie ou Science de Dieu, des deux autres sciences que sont la Science de l’homme et la Science de la nature. Le progrès va se faire avec ces deux Sciences, sans la Théologie. Bergier revient sur cette séparation traduite par l’évincement des théologiens de l’entreprise encyclopédique des Lumières. Il remplit alors parfaitement le rôle demandé par Panckoucke de corriger et de compléter celle que ce dernier appelle la « première Encyclopédie» voulant être le directeur de la seconde Encyclopédie. (shrink)

This book highlights some of the most pressing safety, ethical, legal and societal issues related to the diverse contexts in which robotic technologies apply. Focusing on the essential concept of well-being, it addresses topics that are fundamental not only for research, but also for industry and end-users, discussing the challenges in a wide variety of applications, including domestic robots, autonomous manufacturing, personal care robots and drones.

We present in this paper a novel ontological theory of events whose central tenet is the Aristotelian distinction between the object that changes and the actual subject of change, which is what we call an individual quality. While in the Kimian tradition events are individuated by a triple ⟨ o, P, t ⟩, where o is an object, P a property, and t an interval of time, for us the simplest events are qualitative changes, individuated by a triple ⟨ o, (...) q, t ⟩, where q is an individual quality inhering in o or in one of its parts. Detaching the individuation of events from the property they exemplify results in a fine-grained theory that keeps metaphysics and semantics clearly separate, and lies between the multiplicative and the unitarian approaches. We discuss then the way language refers to events, observing that, in most cases, event descriptions refer to complex, cognitively relevant clusters of co-occurring qualitative changes, which exhibit a synchronic structure depending on the way they are described. Contra Bennett, who famously argued that the semantics of event names ultimately depends on “local context and unprincipled intuitions”, we show how the lexicon provides systematic principles for individuating such clusters and classifying them into kinds. Finally, we address some open challenges in the semantics of locative and manner modifiers. (shrink)

BackgroundClinical ethics case consultations (CECCs) provide a structured approach in situations of ethical uncertainty or conflicts. There have been increasing calls in recent years to assess the quality of CECCs by means of empirical research. This study provides detailed data of a descriptive quantitative and qualitative evaluation of a CECC service in a department of cardiology and intensive care at a German university hospital.MethodsSemi-structured document analysis of CECCs was conducted in the period of November 1, 2018, to May 31, 2020. (...) All documents were analysed by two researchers independently.ResultsTwenty-four CECCs were requested within the study period, of which most (n = 22; 92%) had been initiated by physicians of the department. The patients were an average of 79 years old (R: 43–96), and 14 (58%) patients were female. The median length of stay prior to request was 12.5 days (R: 1–65 days). The most frequent diagnoses (several diagnoses possible) were cardiology-related (n = 29), followed by sepsis (n = 11) and cancer (n = 6). Twenty patients lacked decisional capacity. The main reason for a CECC request was uncertainty about the balancing of potential benefit and harm related to the medically indicated treatment (n = 18). Further reasons included differing views regarding the best individual treatment option between health professionals and patients (n = 3) or between different team members (n = 3). Consensus between participants could be reached in 18 (75%) consultations. The implementation of a disease specific treatment intervention was recommended in five cases. Palliative care and limitation of further disease specific interventions was recommended in 12 cases.ConclusionsTo the best of our knowledge, this is the first in-depth evaluation of a CECC service set up for an academic department of cardiology and intensive medical care. Patient characteristics and the issues deliberated during CECC provide a starting point for the development and testing of more tailored clinical ethics support services and research on CECC outcomes. (shrink)

Tracer le panorama de l'apologétique à l'âge classique n'est pas chose facile, tant sont multiples les perspectives philosophiques et diverses les formes littéraires. La tentation est alors grande d'aligner les monographies. Le colloque de Metz (16-18 octobre 2008), dont sont issues les contributions du présent ouvrage, a choisi d'appréhender cette diversité foisonnante et mouvante en la soumettant à une unique approche, la question du croire. Tenant de l'imaginaire et du rationnel, la foi manifeste l'ambition de réaliser la synthèse du sentiment (...) et de la raison. La théologie pascalienne de la grâce fournit des éléments de réponse pour faire cohabiter ces deux principes, constituant le matériau dont d'innombrables apologies se nourriront pendant plus d'un siècle. De 1650 à 1802, de Pascal à Chateaubriand, en contexte catholique comme en contexte protestant, la réflexion est inlassablement reprise sur la possibilité de rendre raison de sa foi à autrui, comme le demande saint Pierre (1 P 3, 15), alors que les progrès de l'histoire, de l'exégèse biblique ou des sciences de la nature en renouvellent les conditions. Mais peu à peu le sujet s'affirme comme la preuve première : son expérience de la foi, le témoignage qu'il en rend, l'espace de parole qu'il ouvre à l'autre, pour mettre ses idées en débat et engager un possible dialogue, sont les nouveaux moyens de la persuasion et de la conversion. (shrink)

Fieldwork is a project in which, according to Rose (1997, p. 316), researcher, researched and research make each other, yet far more attention has been given to the making of the research and researcher than to the researched. Focusing on three aspects of the research process (the researcher's presence in the field, the research topic and the choice of methods), this paper uses examples from the author's own fieldwork to debate whether it is possible to shape fieldwork such that the (...) knowledges created and consumed in the field by the researched serve to destabilise dominant discourses of race, gender and age. (shrink)

Fieldwork is a project in which, according to Rose (1997, p. 316), researcher, researched and research make each other, yet far more attention has been given to the making of the research and researcher than to the researched. Focusing on three aspects of the research process (the researcher's presence in the field, the research topic and the choice of methods), this paper uses examples from the author's own fieldwork to debate whether it is possible to shape fieldwork such that the (...) knowledges created and consumed in the field by the researched serve to destabilise dominant discourses of race, gender and age. (shrink)

Au début du xviie siècle, on enseignait couramment dans les écoles que l’air était un élément léger, c’est-à-dire qu’il n’avait pas de poids et que les éléments pesants perdaient de leur gravité lorsqu’ils se trouvaient dans leur lieu naturel : l’eau dans l’eau, la terre dans la terre. On s’accordait en outre à déclarer que, si aucune contradiction logique n’empêche la toute puissance créatrice de créer un espace vide, en fait, les forces de la nature sont ainsi agencées que le (...) vide ne peut p... (shrink)

Au début du xviie siècle, on enseignait couramment dans les écoles que l’air était un élément léger, c’est-à-dire qu’il n’avait pas de poids et que les éléments pesants perdaient de leur gravité lorsqu’ils se trouvaient dans leur lieu naturel : l’eau dans l’eau, la terre dans la terre. On s’accordait en outre à déclarer que, si aucune contradiction logique n’empêche la toute puissance créatrice de créer un espace vide, en fait, les forces de la nature sont ainsi agencées que le (...) vide ne peut p... (shrink)

1 – La première lettre du père Noël et la réponse de Pascal Parmi les lecteurs des Expériences nouvelles, un des moins intéressés ne fut pas le P. Noël, ancien professeur de Descartes au Collège des Jésuites de La Flèche, recteur du Collège de Clermont à Paris, alors dans sa soixante-dixième année. Homme de prudence et de transition, il s’efforçait de concilier les nouveautés du cartésianisme avec les axiomes traditionnels de l’École. La hardiesse avec laquelle Pascal soutenait le vid...

1 – La première lettre du père Noël et la réponse de Pascal Parmi les lecteurs des Expériences nouvelles, un des moins intéressés ne fut pas le P. Noël, ancien professeur de Descartes au Collège des Jésuites de La Flèche, recteur du Collège de Clermont à Paris, alors dans sa soixante-dixième année. Homme de prudence et de transition, il s’efforçait de concilier les nouveautés du cartésianisme avec les axiomes traditionnels de l’École. La hardiesse avec laquelle Pascal soutenait le vid...

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Les travaux sociologiques ne manquent pas pour souligner la précarité de l’emploi des artistes et de leur carrière. Un questionnement émerge de ce constat : pourquoi des individus souhaitent-ils s’engager dans un secteur d’activité marqué du sceau de l’incertitude? Pourquoi et comment certains persistent-ils malgré les épreuves? En relatant les récits d’artistes en devenir, l’ouvrage de J-C. Pita Castro apporte un éclairage complémentaire au travail de L. Sibaud, qui analysait conjointement..

In this article I will analyze the conception of moral responsibility proposed by P.F. Strawson in "Freedom and Resentment". I will argue that this conception is relevant for thinking about some aspects of the current COVID-19 pandemic, in particular, those related to cooperation between individuals and its affective dimension.